PK/PD of nitrofurantoin

There are no recent pharmacokinetic data available or studies that linke pharmacokinetic (PK) with pharmacodynamic (PD) information. The PK/PD index and correlation with outcome is not known.

The FP7 funded project AIDA (Preserving old antibiotics for the future) will identify the optimal dosing regimens and treatment duration based on sound PK/PD studies.In vitro activity and PK/PD studies, animal PK/PD studies, pharmacokinetic studies in volunteers and patients, as well as a clinical study in outpatients with acute lower urinary tract infections at risk for multidrug resistant pathogens will increase our knowledge base. Finally drug exposure values will be related to clinical outcome.

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